Abstract：This article is to introduce the chief physician ZHANG Zhaolan's clinical experience in treating functional dyspepsia by regulating the liver and spleen. The pathogenesis of stuffiness and fullness is deficiency-excess complex， and the location of disease is the stomach， which is closely related to the liver and spleen. That is， the liver fails in free coursing and the spleen in transportation， leading to disordered upward and downward qi movement of the spleen and stomach. Based on the idea of “regulating liver and spleen”， chief physician ZHANG put forward the treatment method of “thickening earth qi，picking sprouts，unblocking the qi route”，and created the prescription for removing stuffiness by regulating the liver and spleen. Through flexible modification and combined with non-prescription medicines，good curative effects have been achieved.