Abstract： Objective： To investigate the clinical effect of hot compress with moxa-salt packet at Zhongwan point (RN12) combined with Ondansetron Hydrochloride Tablets in preventing hematopathy chemotherapy-induced nausea and vomiting (CINV). Methods： A total of 108 cases of patients with hematopathy CINV who received chemotherapy were selected as the study subjects and divided into the control group and the study group according to the random number table method， with 54 cases in each group. The control group was treated with Ondansetron Hydrochloride Tablets， and the study group was treated with hot compress with moxa-salt packet at Zhongwan point combined with Ondansetron Hydrochloride Tablets. The clinical effects， traditional Chinese medicine syndrome scores， grading of nausea and vomiting，Functional Life Index-Emesis (FLIE) scores，and incidence of adverse reactions after treatment were compared between two groups. Results： After treatment， the total effective rate was 96.30% in the study group， and 83.33% in the control group， the difference being significant (P＜0.05). The improvement in the grading of nausea and vomiting in the study group was better than that in the control group，the difference being significant (P＜0.05). After treatment，the symptom scores of belching and acid reflux， loss of appetite， fatigue and weakness in the study group were lower than those in the control group，the difference being significant (P＜0.05). On the fifth and twenty-first day after treatment， the FLIE scores in the study group were higher than those in the control group (P＜0.05). During the treatment period， the incidence of adverse reactions was 1.85% in the study group， and 12.96% in the control group， the difference being significant (P＜0.05). Conclusion： The combination of hot compress with moxa-salt packet at Zhongwan point and antiemetic drugs has a significant curative effect on CINV in patients with hematopathy. It can effectively improve TCM syndromes， reduce reactions of nausea and vomiting ，improve quality of life，and is relatively safe.