Abstract： Objective： To observe the effects of Huoxue Xingnao Decoction combined with Fasudil on Lindegaard indexes and vascular endothelial function in patients with cerebral vasospasm (CVS) after interventional embolization of cerebral aneurysms. Methods：A total of 80 cases of patients with CVS after interventional embolization of cerebral aneurysm were randomly divided into the control group and the combination group， with 40 cases in each group. The control group was treated with Fasudil， and the combination group was additionally treated with Huoxue Xingnao Decoction based on the treatment of the control group. After two weeks of treatment，neurological function [Chinese Stroke Scale (CSS)]，state of consciousness [Glasgow Coma Scale (GCS)]， transcranial Doppler ultrasound detection parameters [mean flow velocity of middle cerebral artery (MCA-Vm)，mean flow velocity of extracranial internal carotid artery (VICA-Vm)， and Lindegaard indexes]， vascular endothelial function indexes [plasma endothelin-1 (ET-1) and nitric oxide (NO)] and the incidence of adverse reactions were compared before and after treatment between the two groups. Results：After treatment，CSS scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and GCS scores were increased when compared with those before treatment (P＜0.05)； the CSS score in the combination group was lower than that in the control group (P＜0.05)， and the GCS score was higher than that in the control group (P＜0.05). After treatment， MCA-Vm， VICA-Vm and Lindegaard indexes in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above three indexes in the combination group were lower than those in the control group (P＜0.05). After treatment，the ET-1 levels in the two groups were decreased when compared with those before treatment (P＜0.05)，and the NO levels were increased when compared with those before treatment (P＜0.05)；the ET-1 level in the combination group was lower than that the in control group (P＜0.05)，and the NO level was higher than that in the control group before treatment (P＜0.05). The incidence of adverse reactions was 15.00% in the combination group and 10.00% in the control group，there being no significant difference between the two groups (P＞0.05). Conclusion： Huoxue Xingnao Decoction combined with Fasudil for patients with CVS patients after interventional embolization of cerebral aneurysm can significantly reduce vascular endothelial injury， effectively regulate intracranial and extracranial blood flow velocity， and improve neurological function and state of consciousness.