Abstract： Objective： To observe the clinical effect of the therapy of Wuling Capsules combined with Dexamethasone intramural infusion on chronic tinnitus. Methods： A total of 160 patients with chronic tinnitus were divided into the control group and the observation group according to random number table method， with 80 patients in each group. The control group was treated with Dexamethasone Intramural Infusion，and the observation group was additionally treated with Wuling Capsules based on the treatment of the control group. Both groups were treated for four weeks and followed up for one month. The clinical effects and incidence of adverse reactions，and Tinnitus Evaluation Questionnaire (TEQ)，Tinnitus Handicap Inventory (THI)， Pittsburgh Sleep Quality Index (PSQI)， traditional Chinese medicine (TCM) syndrome scores and levels of γ-aminobutyric acid (GABA) and 5-hydroxytryptamine (5-HT) were compared before and after treatment in the two groups. Results： The total effective rate was 85.00% in the observation group and 68.75% in the control group， the difference being significant (P＜0.05). After treatment， the TEQ scores in both groups were decreased when compared with those before treatment (P＜0.05)， and the TEQ score in the observation group was lower than that in the control group (P＜0.05). After treatment， function， affection and severity scores of THI in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above three scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the serum GABA levels in the two groups were increased when compared with those before treatment (P＜0.05)， and the 5-HT levels were decreased when compared with those before treatment (P＜0.05)，and the GABA level in the observation group was higher than that in the control group (P＜0.05)，and the 5-HT level was lower than that in the control group (P＜0.05). After treatment， the PSQI scores in both groups were decreased when compared with those before treatment (P＜0.05)，and the PSQI score in the observation group was lower than that in the control group (P＜0.05). After treatment， the TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the TCM syndrome scores in the observation group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 7.50% in the observation group and 18.75% in the control group，the difference being significant (P＜0.05). Conclusion： The therapy of Dexamethasone intramural infusion combined with Wuling Capsules has a significant therapeutic effect on chronic tinnitus， which can alleviate clinical symptoms， improve auditory function， enhance sleep quality and reduce the incidence of adverse reactions.