Effect of Fuyuan Huoxue Decoction on Postoperative Lumbar Function and Vertebral Structure of Patients with Lumbar Spinal Stenosis of Qi Stagnation and Blood Stasis Type
Abstract: Objective: To observe the effect of Fuyuan Huoxue Decoction on postoperative lumbar function and vertebral structure of patients with lumbar spinal stenosis of qi stagnation and blood stasis type. Methods:A total of 70 cases of patients with lumbar spinal stenosis of qi stagnation and blood stasis type, who were treated with unilateral biportal endoscopic discectomy (UBE),were selected and divided into the control group and the observation group according to the random number table method,with 35 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with Fuyuan Huoxue Decoction based on the treatment of the control group. The length of hospital stay, clinical effects, inflammatory indexes [levels of tumor necrosis factor- α (TNF- α), monocyte chemoattractant protein-1 (MCP-1),interleukin-1β (IL-1β),interleukin-6 (IL-6)],coagulation function indexes [fibrinogen (FIB) level , prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT)], vertebral structure indexes [the height of anterior, middle and posterior edges of injured vertebrae], vertebral function-related scores [Visual Analogue Scale (VAS), Oswestry Disability Index (ODI),intermittent claudication scores] and complication rates were compared between the two groups. Results: The length of hospital stay in the observation group was shorter than that in the control group (P<0.05). After 14 days of surgery, the clinical effect of fine rate was 91.43% in the observation group,higher than that of 68.57% in the control group (P<0.05). After 14 days of surgery,the levels of TNF- α, MCP-1, IL-1β and IL-6 in serum in the two groups were decreased when compared with those before treatment (P<0.05),and the levels of TNF-α,MCP-1,IL-1β and IL-6 in serum in the observation group were lower than those in the control group (P<0.05). After 14 days of surgery,the levels of serum FIB in the two groups were decreased when compared with those before treatment,and the level of serum FIB in the observation group was lower than that in the control group (P<0.05). PT,APTT and TT in the two groups were prolonged when compared with those before treatment (P<0.05),and PT,APTT and TT in the observation group were longer than those in the control group (P<0.05). After 14 days of surgery,there was no significant difference being found in the comparison of the height of anterior,middle and posterior edges of injured vertebrae before and after treatment and no significant difference between the two groups (P>0.05). After 14 days of surgery,VAS,ODI and intermittent claudication scores in the two groups were decreased when compared with those before treatment (P<0.05), and VAS, ODI and intermittent claudication scores in the observation group were lower than those in the control group (P< 0.05). During the treatment period,the complication rate was 2.86% in the observation group and 8.57% in the control group,there being no significant difference (P>0.05). Conclusion:Fuyuan Huoxue Decoction for patients after UBE for lumbar spinal stenosis of qi stagnation and blood stasis type can effectively relieve their inflammatory responses and coagulation function of the body, improve the lumbar function and shorten the length of hospital stay.