Abstract：Objective：To observe the clinical effect of modified Shengmai Yin combined with western medicine for chronic heart failure with qi and yin deficiency syndrome. Methods： A total of 76 cases of patients with chronic heart failure with qi and yin deficiency syndrome were selected and divided into the Shengmai Yin group and the control group according to the random number table method，with 38 cases in each group. The control group received western medicine treatment， and the observation group received modified Shengmai Yin based on the treatment of the control group. Both groups were treated for 4 weeks. The clinical effects，symptom scores，heart function indexes [left ventricular ejection fraction (LVEF)，and stroke volume (SV)]，levels of N-terminal pro b-type natriuretic peptide (NT proBNP) in serum，6-minute walk test (6MWT) distance，and Minnesota Living with Heart Failure Questionnaire (MDCAT) scores were compared between the two groups. The adverse reactions were recorded. Results： After treatment， the total effective rate was 94.74% in the Shengmai Yin group，higher than that of 78.95% in the control group， the difference being significant (P＜0.05). The symptom scores and MDCAT scores in the two groups were decreased when compared with those before treatment， LVEF and SV were increased when compared with those before treatment， NT-proBNP levels in serum were decreased when compared with those before treatment， and 6MWT distance were increased when compared with those before treatment， differences being significant (P＜0.05). The symptom score and MDCAT score in the Shengmai Yin group were lower than those in the control group，LVEF and SV were higher than those in the control group，the NT-proBNP level in serum was lower than that in the control group，and the 6MWT distance was greater than that in the control group，differences being significant (P＜0.05). There was no drug-related adverse reaction in the two groups. Conclusion： Modified Shengmai Yin combined with western medicine for chronic heart failure with qi and yin deficiency syndrome can effectively improve the clinical symptoms of patients and help improve their heart function and quality of life.