Abstract： Objective： To observe the curative effect of the therapy of modified Qingzhen Decoction combined with minimally invasive hematoma removal on hypertensive intracerebral hemorrhage. Methods： A total of 98 patients with hypertensive intracerebral hemorrhage were selected as the study subjects and divided into the trial group and the control group according to the random number table method ， with 49 cases in each group. The control group was given minimally invasive hematoma removal， and routine western medicine after surgery， and the trial group was additionally treated with modified Qingzhen Decoction based on the treatment of the control group. The intracranial pressure (ICP)，scores of National Institute of Health Stroke Scale (NIHSS) and Glasgow Coma Scale (GCS)，volume and duration of cerebral edema ， levels of serum tumor necrosis factor- α (TNF- α) ， nerve growth factor (NGF) and matrix metalloproteinase-9 (MMP9) and traditional Chinese medicine (TCM) syndrome scores were compared between the two groups. Results：Before surgery，there was no significant difference being found in the comparison of ICP value between the two groups (P＞0.05). The moment， 24 hours， 72 hours and one week after surgery，the ICP value in the trial group at the same time point was respectively lower than that in the control group (P＜0.05). Before surgery， there was no significant difference being found in the comparisons of scores of NIHSS and GCS between the two groups (P＞0.05)；fourteen days after surgery， the NIHSS score in the trial group was lower than that in the control group (P＜0.05)， and the GCS score was higher than that in the control group (P＜0.05). After surgery， the volume and duration of cerebral edema in the trail group were lower than those in the control group， the difference being significant (P＜ 0.05). Before surgery，there was no significant difference being found in the comparisons of levels of serum TNF- α，MMP-9 and NGF between the two groups (P＞0.05). Fourteen days after surgery，the levels of serum TNF- α and MMP-9 in the two groups were decreased when compared with those before surgery (P＜0.05)，and the serum NGF levels were increased when compared with those before surgery (P＜0.05)； the levels of serum TNF- α and MMP-9 in the trial group were lower than those in the control group (P＜ 0.05)，and the NGF level was higher than that in the control group (P＜0.05). Before surgery，there was no significant difference being found in the comparisons of TCM syndrome scores of hemiplegia， deviated mouth and eyes，and delirium between the two groups (P＞0.05)；fourteen days after surgery，the above three TCM syndrome scores in the trial group were lower than those in the control group (P＜0.05). Conclusion： The therapy of modified Qingzhen Decoction combined with minimally invasive hematoma removal can decrease the ICP of patients with hypertensive intracerebral hemorrhage，mitigate the stroke symptoms，GCS and cerebral edema，and improve the TCM syndromes and inflammatory responses.