Abstract： Objective： To research the medication rules of Professor LIANG De in the treatment of lumbar disc herniation based on data mining. Using the V2.5 software of Traditional Chinese Medicine Inheritance Assistance Platform，to analyze the medication rules of Professor LIANG De in the treatment of lumbar disc herniation. Methods： The outpatient prescriptions of Professor LIANG De for treating lumbar disc herniation were collected， and the data was put into Traditional Chinese Medicine Inheritance Assistance Platform V2.5. Data mining methods such as rule analysis， improved mutual information method， complex system entropy clustering， and unsupervised entropy hierarchical clustering integrated in the software were applied to analyze Professor LIANG De's prescriptions for treating lumbar disc herniation. Results：A total of 75 prescriptions were included，involving 55 medicinals. Among them，the frequency of medicinal use was ≥ 10 times， with a total of 24 medicinals. The top 10 medicinals were： Angelicae Pubescentis Radix， Rehmanniae Radix， Achyranthis Bidentatae Radix， Persicae Semen， Bupleuri Radix，Dipsaci Radix，Paeoniae Radix Alba，Eucommiae Cortex，Glycyrrhizae Radix et Rhizoma Praeparata cum Melle， and Glycyrrhizae Radix et Rhizoma. Association rule analysis， with a support number of 15 (support score ≥ 30%) and a confidence rate of 0.60，resulted in 32 couplet medicines with a frequency of ≥ 30. The top 10 couplet medicines were：Paeoniae Radix Alba-Bupleuri Radix，Eucommiae Cortex-Dipsaci Radix， Dipsaci Radix-Angelicae Pubescentis Radix， Eucommiae Cortex-Angelicae Pubescentis Radix， Rehmanniae Radix-Achyranthis Bidentatae Radix， Rehmanniae Radix-Persicae Semen，Eucommiae Cortex-Dipsaci Radix-Angelicae Pubescentis Radix，Rehmanniae Radix-Pubescentis Radix Angelicae， Rehmanniae Radix-Dipsaci Radix， and Persicae Semen-Achyranthis Bidentatae Radix. Improved mutual information analysis， with a set correlation coefficient of 5 and penalty coefficient of 2， obtained core combinations (correlation coefficient ≥ 0.05). After further clustering and evolution， 8 core combinations were obtained， each consisting of 3 Chinese medicinals. Unsupervised entropy hierarchical clustering analysis obtained 4 potential new combinations. Conclusion： Professor LIANG De's medication for lumbar disc herniation mainly focuses on tonifying qi，strengthening the spleen，dispelling dampness， and promoting qi， promoting blood circulation， and relieving pain， which is often supplemented with medicinals such as tonifying the kidney and strengthening bones， relaxing tendons and activating collaterals， and nourishing yin. This reflects his clinical experience in diagnosing and treating lumbar disc herniation from the perspectives of spleen and kidney， taking into account the fundamental principles of nature，and the treatment principle of "balancing hardness and softness，and emphasizing both sinew and bones".