Abstract： Objective： To observe the curative effect of Exian Huaban Decoction combined with Adalimumab for plaque psoriasis，and its effect on symptom relief time，transepidermal water loss，and levels of human beta-defensin-2 (hBD-2) in serum. Methods：A total of 86 patients with plaque psoriasis were selected and divided into the combination group and the control group according to the random number table method，with 43 cases in each group. During this period，2 cases were lost in each group， and finally 41 cases were obtained in each group. The control group was treated with Adalimumab Injection， and the combination group was treated with Exian Huaban Decoction based on the treatment of the control group. The clinical effects and symptom relief time were compared between two groups，and the changes in skin barrier function related indexes and serum hBD-2 levels were compared before and after treatment. Results：The total clinical effective rate was 95.12% in the combination group，and 73.17% in the control group ， the difference being significant (P ＜ 0.05). After treatment ， the psoriasis area and severity index(PASI) scores in the two groups were decreased when compared with those before treatment (P＜ 0.05)，and the PASI score in the combination group was lower than that in the control group (P＜0.05). After treatment，the areas and infiltration relief time of symptoms including erythema，scales，and itching in the combination group were shorter than those in the control group (P＜0.05). After treatment， the cortical content and stratum corneum moisture content in the two groups were increased when compared with those before treatment (P＜0.05)，and the loss of epidermal moisture was decreased when compared with that before treatment (P＜0.05)； the cortical content and stratum corneum moisture content in the combination group were higher than those in the control group (P＜0.05)， and the loss of epidermal moisture was lower than that in the control group (P＜0.05). After treatment，the hBD-2 levels in serum in the two groups were decreased when compared with those before treatment (P＜0.05)， and the hBD-2 level in serum in the combination group was lower than that in the control group (P＜0.05). Conclusion：The combination of Exian Huaban Decoction and Adalimumab for plaque psoriasis can effectively alleviate clinical symptoms，reduce itching，reduce psoriasis area，and improve the quality of life of patients.