Abstract： Objective： To observe the effect of modified Yunv Jian on blood glucose and pancreatic β cell function in patients with type 2 diabetes mellitus (T2DM) with intense stomach heat syndrome. Methods： A total of 106 T2DM patients with intense stomach heat syndrome were selected and divided into the trial group and the control group according to the random number table method，with 53 cases in each group. The control group received routine treatment，and the trial group received modified Yunv Jian based on the treatment of the control group. The clinical effects were compared between the two groups. Before and after treatment， the changes in scores of intense stomach heat syndrome， blood glucose indicators [fasting blood glucose (FBG)，postprandial 2-hour blood glucose (P2hBG)，and hemoglobin A1c (HbA1c)]， and pancreatic β cell function indexes [fasting serum insulin (FINS)， Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)， and Homeostasis Model Assessment of Β-Cell Function (HOMA) - β)] were compared between the two groups. Results： The total clinical effective rate was 94.34% in the trial group，and 77.36% in the control group，the difference being significant (P＜0.05). After treatment，the scores of epigastric burning，bad breath，thirst and coldness，secondary symptoms，and total scores in the two groups were decreased when compared with those before treatment (P＜0.05). The scores of the above four items and total score in the trial group were lower than those in the control group (P＜0.05). After treatment， the values of FBG， P2hBG， and HbA1c in the two groups were decreased when compared with those before treatment (P＜0.05)， and the values of FBG， P2hBG， and HbA1c in the trial group were lower than those in the control group (P＜0.05). After treatment，the values of FINS and HOMA-IR in the two groups were decreased when compared with those before treatment (P＜ 0.05)，and HOMA- β values were increased when compared with those before treatment (P＜0.05)；the values of FINS and HOMA-IR in the trial group were lower than those in the control group (P＜0.05)，and HOMA- β value was higher than that in the control group (P＜0.05). Conclusion：Modified Yunv Jian has a significant curative effect in treating T2DM with intense stomach heat syndrome， which can effectively relieve clinical symptoms，lower blood glucose levels，and improve pancreaticβ cell function.