Abstract： Objective： To observe the clinical effect of Huanglian Wendan Decoction assisting Compound Sodium Valproate and Valproic Acid Sustained Release Tablets for epilepsy of phlegm-fire harassing spirit type. Methods： A total of 62 cases patients with epilepsy of phlegm-fire harassing spirit type admitted to The Second People's Hospital of Lishui were divided into the control group and the treatment group by random number table methed， with 31 cases in each group. The control group was treated with Compound Sodium Valproate and Valproic Acid Sustained Release Tablets orally， and the treatment group was treated with Huanglian Wendan Decoction and Compound Sodium Valproate and Valproic Acid Sustained Release Tablets. Traditional Chinese medicine (TCM) syndrome scores，the scores of Mini-Mental State Examination (MMSE)， Montreal Cognitive Assessment Scale (MoCA) and Quality of Life in Epilepsy-31-P (QOLlE-31)， and inflammatory factors were compared between two groups. The clinical effects and the incidence of adverse reactions were evaluated in two groups. Results： The total effective rate was 96.77% in treatment group，higher than that of 77.42% in control group (P＜0.05). After treatment， TCM syndrome scores and the levels of interleukin-6 (IL-6)， interleukin-1β (IL-1β)， tumor necrosis factor- α (TNF- α) in the two groups were decreased (P＜0.05)， and the above indexes in treatment group were lower than those in the control group (P＜0.05). After treatment， the scores of MMSE， MoCA， and QOLlE-31 in the two groups were increased when compared with those befor treatment (P＜0.05)；and the above scores in treatment group were higher than those in the control group (P＜0.05). The incidence of adverse reactions was 6.45% in treatment group，lower than that of 29.03% in control group (P＜0.05). Conclusion：Huanglian Wendan Decoction assisting Compound Sodium Valproate and Valproic Acid Sustained Release Tablets has a definite curative effect for epilepsy of phlegm-fire harassing spirit type， which can improve symptoms， enhance cognitive function and quality of life， and reduce inflammatory reactions，with high safety.