Abstract：Objective：To observe the clinical effect of modified HOU's Hei San combined with median nerve electrical stimulation on disorder of consciousness after ischemic stroke. Methods ： A total of 94 cases of patients with disorder of consciousness after ischemic stroke were divided into the control group and the observation group according to the random number table method， with 47 cases in each group. The control group was treated with median nerve electrical stimulation， and the observation group was additionally treated with modified HOU's Hei San based on the treatment of the control group. Traditional Chinese medicine (TCM) syndrome scores， the scores of Glasgow Coma， Barthel Indexes， and National Institutes of Health Stroke Scale (NIHSS)， and the levels of serum neurofactors (5- hydroxytryptamine， brain-derived neurotrophic factor， glial fibrillary acidic protein) were compared between two groups before and after treatment； clinical effects and the incidence of post-stroke major adverse cardiovascular events (MACE) were evaluated in the two groups. Results：During the treatment， one case was excluded from both group， and these was 46 cases who completed the study in each group. After treatment，the total effective rate was 93.48% in the observation group，higher than that of 78.26% in the control group (P＜0.05). After treatment，Glasgow Coma scores，Barthel Indexes，and the levels of serum 5-hydroxytryptamine and brain-derived neurotrophic factor in the two groups were increased when compared with those before treatment (P＜0.05)， and TCM syndrome scores， NIHSS scores， and the levels of serum glial fibrillary acidic protein were decreased when compared with those before treatment (P＜0.05)； Glasgow Coma scores， Barthel Indexes， and the levels of serum 5- hydroxytryptamine and brain-derived neurotrophic factor in the observation group were higher than those in the control group (P＜0.05)， and TCM syndrome scores， NIHSS scores， and the levels of serum glial fibrillary acidic protein in the observation group were lower than those in the control group (P＜0.05). The incidence of post-stroke MACE in the observation group was lower than that in the control group (P＜0.05). Conclusion： Modified HOU's Hei San combined with median nerve electrical stimulation has significant clinical effects in the treatment of disorder of consciousness after ischemic stroke，which can regulate the levels of neurokines in patients， improve neurological function， and reduce the incidence of post-stroke MACE.