Abstract： Objective： To observe the clinical effect of the therapy of Shuangge Jiejiu Prescription combined with Naloxone Hydrochloride Injection on patients with acute alcohol intoxication (AAI) in noncoma stage. Methods：A total of 90 AAI patients in non-coma stage were selected as the study subjects and randomly divided into the control group and the trial group， with 45 cases in each group. The control group was treated with Naloxone Hydrochloride Injection and the trial group was additionally given oral administration of Shuangge Jiejiu Prescription based on the treatment of the control group. The clinical effects， incidence of adverse reactions， breath alcohol concentration， traditional Chinese medicine syndrome scores， and levels of liver function indexes， including alanine transaminase (ALT)， aspartate aminotransferase (AST) and γ -glutamyl transpeptidase (GGT) were compared between the two groups before and after treatment. Results： The total effective rate was 91.11% in the trial group and 73.33% in the control group，the difference being significant (P＜0.05). After treatment，the scores of distending pain in the head and eyes， nausea and vomiting， mania and irritability， distention and fullness in ribs and abdomen，red complexion and eyes，jaundice and bitter mouth and thirst and the total scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above scores in the trial group were lower than those in the control group. After 4 hours of treatment， the breath alcohol concentration in the two groups were respectively lower than that before treatment and after 1 hour of treatment (P＜0.05)，and showed a downward trend (P＜0.05)；the breath alcohol concentration in the trial group at the same time point was lower than that in the control group (P＜0.05). After treatment，the levels of ALT，AST and GGT in the two groups were decreased when compared with those before treatment (P＜ 0.05)，and the above three levels in the trial group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 17.77% in the trial group and 44.44% in the control group， the difference being significant (P＜0.05). Conclusion：The Shuangge Jiejiu Prescription can improve the clinical symptoms of AAI patients in non-coma stage， enhance the curative effect， effectively promote the metabolism and excretion of ethanol and protect the liver function with less adverse reactions.