Abstract： Objective： To observe the clinical effect of the therapy of Shuxuening Injection combined with western medicine on senile patients with unstable angina pectoris of coronary heart disease with heart blood stasis obstruction syndrome and its effect on vascular endothelial function. Methods ： A total of 108 cases of senile patients with unstable angina pectoris of coronary heart disease with heart blood stasis obstruction syndrome were selected and divided into the Shuxuening group and the control group according to the random number table method， with 54 cases in each group. Among them ， 1 case dropped out in the Shuxuening group and 3 cases dropped out in the control group； finally 53 and 51 cases were respectively included in each group. The control group was treated with western medicine and the Shuxuening group was additionally given Shuxuening Injection for treatment based on the treatment of the control group. The two groups were treated for 2 months. The clinical effects，times and duration of angina pectoris attack， levels of myocardial enzymes， including serum lactate dehydrogenase (LDH)， creatine kinase isoenzyme (CK-MB) and creatine kinase (CK)， and levels of vascular endothelial function indexes， including serum endothelin (ET) and nitric oxide (NO) were compared between the two groups； the incidence of adverse reactions was recorded. Results： After treatment， the clinical effect in the Shuxuening group was better than that in the control group by the rank sum test (P＜0.05). After treatment， the times of angina pectoris attack in the two groups were reduced when compared with those before treatment (P＜0.05)， and the duration of angina pectoris attack was shortened when compared with that before treatment (P＜0.05)； the times of angina pectoris attack in the Shuxuening group were less than those in the control group (P＜0.05)，and the duration of angina pectoris attack was shorter than that in the control group (P＜0.05). After treatment，the levels of serum LDH，CK-MB and CK were decreased when compared with those before treatment (P＜0.05)，and the above levels in the Shuxuening group were lower than those in the control group (P＜0.05). After treatment， the serum ET levels in the two groups were decreased when compared with those before treatment (P＜0.05)， and the serum NO levels were increased when compared with those before treatment (P＜0.05)； the serum ET level in the Shuxuening group was lower than that in the control group (P＜0.05)，and the serum NO level was higher than that in the control group (P＜0.05). During treatment， the incidence of adverse reactions was 5.66% in the Shuxuening group and 7.84% in the control group，there being no significance in the difference (P＞0.05). Conclusion：The therapy of Shuxuening Injection combined with western medicine can enhance the clinical effect on senile patients with unstable angina pectoris of coronary heart disease with heart blood stasis obstruction syndrome，mitigate the clinical symptoms of patients and improve the myocardial injuries.