Abstract： Objective： To observe the clinical effect of the therapy of Xinshuai No. 1 Prescription combined with conventional western medicine on heart failure with preserved ejection fraction of qi and yin deficiency complicated with blood stasis type. Methods： A total of 60 patients with heart failure with preserved ejection fraction of qi and yin deficiency complicated with blood stasis type were selected. They were divided into the control group and the observation group by random number table， with 30 cases in each group. Three cases dropped off naturally in the observation group，and four cases dropped off in the control group. The control group was treated with conventional western medicine， and the observation group was additionally treated with Xinshuai No.1 Prescription based on the treatment of the control group. Both groups were treated for 4 weeks. The traditional Chinese medicine (TCM) syndrome scores， 6- minute walking distance， cardiac function grade of New York Heart Association (NYHA)， and levels of plasma N-terminal pro-B type natriuretic peptide (NT-proBNP) were compared before and after treatment between the two groups. Results： After treatment， the TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the 6-minute walking distance in the two groups was respectively increased when compared with that before treatment (P＜0.05)，and the 6-minute walking distance in the observation group was higher than that in the control group (P＜0.05). After treatment， the cardiac function grade in the two groups was improved when respectively compared with that before treatment (P＜0.05). After treatment， the levels of NT-proBNP in the two groups were decreased when compared with those before treatment (P＜0.05)， and the level of NT-proBNP in the observation group was lower than that in the control group (P＜0.05). Conclusion：The therapy of Xinshuai No.1 Prescription combined with conventional western medicine can lessen the clinical symptoms of patients with heart failure with preserved ejection fraction of qi and yin deficiency complicated with blood stasis type，enhance exercise tolerance，and improve clinical effect.