Abstract：Objective：To observe the curative effect of modified Buyang Huanwu Decoction combined with brain-limb coordinated regulation on post-stroke limb dysfunction. Methods： A total of 96 cases of patients with post-stroke limb dysfunction were selected as the study subjects and divided into the control group and the observation group according to the random number table method， with 48 cases in each group. The control group was treated with routine treatment and brain-limb coordinated regulation， and the observation group was additionally treated with modified Buyang Huanwu Decoction based on the treatment of the control group. Clinical effects were compared between the two groups. Changes in traditional Chinese medicine (TCM) syndrome scores ， serum indicators [C-reactive protein (CRP) and homocysteine (Hcy)]， hemorheological indicators [fibrinogen (Fib)， plasma viscosity， and hematocrit (HCT)]， and scores of Fugl-Meyer Motor Function (FMA)， Berg Balance Scale (BBS)， and Functional Ambulation Categories (FAC) were compared between the two groups before and after treatment. Results： After 4 weeks of treatment， the total clinical effective rate was 95.83% in the observation group and 83.33% in the control group， the difference being significant (P＜0.05). After treatment， each TCM syndrome score in the two groups was decreased when compared with that before treatment (P＜0.05)， and each TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). After treatment， CRP and Hcy in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above two indicators in the observation group were lower than those in the control group (P＜0.05). After 4 weeks of treatment， Fib， plasma viscosity， and HCT in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above three indicators in the observation group were lower than those in the control group (P＜0.05). After 4 weeks of treatment， the scores of FMA，BBS，and FAC in the two groups were increased when compared with those before treatment (P＜0.05)， and the scores of FMA， BBS， and FAC in the observation group were higher than those in the control group (P＜0.05). Conclusion： Modified Buyang Huanwu Decoction combined with brain-limb coordinated regulation for post-stroke limb dysfunction can enhance clinical effects， improve symptoms of decreased muscle strength and tone， relieve inflammation， and promote the recovery of motor function of limbs.