Abstract： Objective： To observe the clinical effect of Weifuchun combined with bismuth quadruple therapy on atrophic gastritis complicated with Helicobacter pylori (Hp) infection and its effect on Hp eradication. Methods：A total of 80 cases of patients with atrophic gastritis and Hp infection were selected as the study objects and divided into the observation group and the control group according to the random number table method，with 40 cases in each group. The control group was treated with bismuth quadruple therapy，and the observation group was treated with Weifuchun combined with bismuth quadruple therapy. The clinical effects，Hp eradication rates，traditional Chinese medicine (TCM) syndrome scores，levels of inflammatory factors [tumor necrosis factor (TNF-α)，interleukin-4 (IL-4)，and interleukin-33 (IL-33)] and growth factors [epidermal growth factor (EGF)， and vascular endothelial growth factor (VEGF)]， and the incidence of adverse reactions were compared between the two groups. Results： The total effective rate was 92.50% in the observation group and 75.00% in the control group，the difference being significant (P＜ 0.05). After 1-month follow-up，the Hp eradication rate was 95.00% in the observation group and 80.00% in the control group，the difference being significant (P＜0.05). After treatment，TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and TCM medicine syndrome score in the observation group was lower than that in the control group (P＜0.05). After treatment，the levels of TNF-α，IL-4 and IL-33 in the two groups were decreased when compared with those before treatment (P＜0.05)，and the three indexes in the observation group were lower than those in the control group (P＜0.05). After treatment，EGF levels in the two groups were decreased when compared with those before treatment (P＜0.05)，and VEGF levels were increased when compared with those before treatment (P＜0.05)；EGF level in the observation group was lower than that in the control group (P＜0.05)， and VEGF level was higher than that in the control group (P＜0.05). During treatment，no serious adverse reaction occurred in the two groups. Conclusion：Weifuchun combined with bismuth quadruple therapy for patients with atrophic gastritis and Hp infection can improve their clinical symptoms， reduce the levels of inflammatory responses，and restore the endothelial function，with a good effect on Hp eradication.