Abstract： Objective： To observe the clinical effect of Dengzhan Shengmai Capsules combined with western medicine on coronary heart disease (CHD) complicated with chronic heart failure (CHF) with dual deficiency of qi and yin syndrome. Methods：A total of 92 cases of patients with CHD complicated with CHF with dual deficiency of qi and yin syndrome were divided into the control group and the treatment group according to the random number table method，with 46 cases in each group. The control group was treated with Trimetazidine Hydrochloride Tablets and Metoprolol Tartrate Tablets， and the treatment group was additionally treated with Dengzhan Shengmai Capsules based on the treatment of the control group. Both groups were treated for 1 month. The clinical effects，traditional Chinese medicine (TCM) syndrome scores， echocardiogram indexes [left ventricular end-diastolic diameter (LVEDD)， left ventricular end-systolic diameter (LVESD) and left ventricular ejection fraction (LVEF)]，and laboratory indexes [N-terminal B-type natriuretic peptide precursor (NT-proBNP)， adiponectin (APN) and matrix metalloproteinase-9 (MMP-9)] were compared between the two groups. Results：After treatment，the total effective rate was 95.65% in the treatment group，higher than that of 80.43% in the control group (P＜0.05). The TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome score in the treatment group was lower than that in the control group (P＜0.05). LVEDD and LVESD in the two groups were decreased when compared with those before treatment (P＜0.05)， and LVEDD and LVESD in the treatment group were lower than those in the control group (P＜0.05). LVEF in the two groups were increased when compared with those before treatment (P＜0.05)， and LVEF in the treatment group was higher than that in the control group (P＜0.05). The levels of NT-proBNP and MMP-9 in serum in the the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of NT-proBNP and MMP-9 in serum in the treatment group were lower than those in the control group (P＜0.05). The levels of serum APN in the two groups were increased when compared with those before treatment (P＜0.05)，and the level of serum APN in the treatment group was higher than that in the control group (P＜0.05). Conclusion：The additional application of Dengzhan Shengmai Capsules based on western medicine for CHD complicated with CHF with dual deficiency of qi and yin syndrome can enhance the clinical effect， effectively relieve symptoms and improve heart function. Its action mechanism can be related to regulating the levels of NT-proBNP，MMP-9 and APN in serum.