Abstract： Objective： To observe the clinical effect of Tongguan Yixin Prescription combined with western medicine for coronary heart disease of qi deficiency and blood stasis type，and the effect on blood lipid and inflammatory indexes， and perform safety evaluation. Methods： A total of 70 cases of patients with coronary heart disease of qi deficiency and blood stasis type were selected and divided into the control group and the trial group according to the random number table method，with 35 cases in each group. Four cases were excluded from the control group，５ cases were excluded from the trial group，and ultimately 31 cases were included in the control group and 30 cases in the trial group. The control group was treated with western medicine， and the trial group was treated with Tongguan Yixin Prescription based on the application of western medicine. Both groups were treated for 4 weeks. The clinical effects were evaluated in the two groups. The Seattle Angina Questionnaire scores and levels of blood lipid and inflammatory indexes were compared in the two groups before and after treatment. The liver function，kidney function， and blood routine in the trial group were detected before and after treatment. Results：After treatment，the total effective rate was 96.67% in the trial group，higher than that of 54.84% in the control group (P＜0.05). After treatment， the scores of physical limitation (PL)， angina stability (AS)， angina frequency (AF)， and disease perception (DP) in the two groups were increased when compared with those before treatment (P＜ 0.05)，the scores of PL，AS，AF，and DP in the trial group were higher than those in the control group (P＜ 0.05). After treatment，the levels of total cholesterol (TC)，triglycerides (TG)，and low-density lipoprotein cholesterol (LDL-C) in the trial group were decreased when compared with those before treatment (P＜ 0.05)， and high-density lipoprotein cholesterol (HDL-C) level was increased when compared with that before treatment (P＜0.05). The HDL-C level in the trial group was higher than that in the control group (P＜ 0.05)，and the difference in LDL-C levels before and after treatment in the trial group was greater than that in the control group (P＜0.05). There was no significant difference being found in the levels of TC， TG， HDL-C，and LDL-C between the control group before and after treatment，as well as in the levels of TC， TG，and HDL-C between the two groups before and after treatment (P＞0.05). After treatment，the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in serum were decreased when compared with those before treatment (P＜0.05)，and the levels of interleukin-10 (IL-10) in serum were increased when compared with those before treatment (P＜0.05)；the IL-6 level in serum in the trial group was lower than that in the control group (P＜0.05)，and the IL-10 level in serum was higher than that in the control group (P＜ 0.05). The difference in levels of TNF - α， IL-6， and IL-10 in serum in the trial group before and after treatment was greater than that in the control group (P＜0.05). There was no significant difference in the comparison of levels of TNF - α in serum between the two groups before and after treatment (P＞0.05). There was no significant difference in the comparison of levels of alanine aminotransferase (ALT)，aspartate aminotransferase (AST)，creatinine (Cr)，hemoglobin (Hb)，and blood platelet count (BPC) in the trial group before and after treatment (P＞0.05). Conclusion： The combination of Tongguan Yixin Prescription and western medicine for coronary heart disease of qi deficiency and blood stasis type is superior to western medicine alone in improving clinical effects and angina pectoris. It can also regulate blood lipids and improve inflammatory indexes with good safety.