Abstract： Objective： To explore the key components and mechanism of Urine C Prescription in treating IgA nephropathy (IgAN) based on network pharmacology. Methods： The targets of Urine C Prescription were obtained by Traditional Chinese Medicine Systems Pharmacology Platform (TCMSP)， PubChem，Swiss ADEM and SwissTargetPrediction. The “medicines- components- targets” interaction network was constructed via Cytoscape 3.9.1 software. The IgAN action targets were obtained by GeneCards， OMIM and DisGeNET platforms. The intersection targets between Urine C Prescription and IgAN were identified and visualized by Venn 2.1， and protein- protein interaction (PPI) network was established by STRING database. The intersection targets were given GO and KEGG enrichment analysis by DAVID database and were visualized under GO and KEGG enrichment analysis through Bioinformatics online platform. Autodock Vina software was used to verify molecular docking，and PyMol software was used to obtain docking results. Results：A total of 70 kinds of active components and 1 363 corresponding action targets of Urine C Prescription were selected， among which 10 key active components were identified. There were 1 593 IgAN-related targets，and after removing the duplicate targets，823 disease targets and 111 intersection targets were obtained. GO enrichment analysis yielded 706 BP items， 63 CC items and 123 MF items. KEGG enrichment analysis showed that 161 pathways were significantly correlated with IgAN. The results of molecular docking showed that there was strong binding activity between the core active components and the core targets. Conclusion： The mechanism of Urine C Prescription in treating IgAN may be the regulation of AGE- RAGE signaling pathway， IL- 17 signaling pathway， lipid and atherosclerosis pathway through quercetin，kaempferol，β-sitosterol and baicalein.