Abstract：Objective：To observe the curative effect of the therapy of Chinese medicine delivered by sonophoresis at Tianshu Point (ST 25) combined with pelvic floor biofeedback on refractory constipation. Methods：A total of 82 patients with refractory constipation were selected as the study subjects and divided into the control group and the study group，with 41 cases in each group. The control group was given pelvic floor biofeedback for treatment， and the study group was treated with Chinese medicine delivered by sonophoresis at Tianshu Point combined with pelvic floor biofeedback. The clinical effects，and the changes of traditional Chinese medicine syndrome scores， and measured values of anorectal pressure indexes [resting anal sphincter pressure (RASP)， maximum systolic anal sphincter pressure (SASP)， maximum rectal tolerance threshold (MRST) and rectal defecation threshold (CRS)] were compared before and after treatment between the two groups. Results：After treatment of one month，the total clinical effective rate was 97.56% in the study group and 85.37% in the control group，the difference being significant (P＜0.05). After treatment，the TCM syndrome scores (the scores of primary and secondary symptoms and the total scores) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the study group were lower than those in the control group (P＜0.05). After treatment of one month，the values of RASP，SASP and CRS in the two groups were decreased when compared with those before treatment (P＜0.05)，and the MRST values were increased when compared with those before treatment (P＜0.05)；the values of RASP，SASP and CRS in the study group were lower than those in the control group (P＜0.05)， and the MRST value was higher than that in the control group (P＜0.05). Conclusion： The therapy of Chinese medicine delivered by sonophoresis at Tianshu Point combined with pelvic floor biofeedback has a good clinical effect on refractory constipation， which can mitigate the symptoms and improve the anorectal function.