Abstract： Objective： To observe the clinical effect of the therapy of children chiropractic combined with acupuncture at Sifeng point on infantile anorexia nervosa of spleen failing in transportation type. Methods：A total of 100 cases with infantile anorexia nervosa of spleen failing in transportation type were divided into the treatment group and the control group according to the block randomization method，with 50 cases in each group. The treatment group was given children chiropractic combined with acupuncture at Sifeng point for treatment，and the control group was treated with the oral administration of Zinc Gluconate Oral Solution. The two groups were treated for 8 weeks. The traditional Chines medicine (TCM) syndrome scores，levels of serum zinc，hemoglobin，cholecystokinin (CCK)，leptin (LEP) and neuropeptide Y (NPY)， clinical effects，recurrence rates of the disease and incidence of adverse reactions were compared before and after treatment between the two groups. Results：The total effective rate was 98.00% in the treatment group， higher than that of 82.00% in the control group (P＜0.05). After treatment， the TCM syndrome scores， and the levels of CCK and LEP in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of serum zinc， hemoglobin and NPY were increased when compared with those before treatment (P＜0.05)；the TCM syndrome scores，and the levels of CCK and LEP in the treatment group were lower than those in the control group (P＜0.05)， and the levels of hemoglobin and NPY were higher than those in the control group (P＜0.05). There was no significant difference being found in the comparison of serum zinc level between the two groups (P＞0.05). The recurrence rate of the disease in the treatment group was higher than that in the control group (P＜0.05). There were no such adverse reactions as vomiting，fainting during acupuncture treatment or allergy in the two groups. Conclusion： The therapy of children chiropractic combined with acupuncture at Sifeng point can significantly improve the clinical symptoms of infantile anorexia nervosa of spleen failing in transportation type and the intake function，and decrease the recurrence rate of the disease.