Abstract： Objective： To observe the curative effect of Angong Niuhuang Pills on intracranial hypertension in patients with cerebral hemorrhage in basal ganglia and its effect on oxidative stress indexes and serum B-type natriuretic peptide (BNP) levels. Methods：A total of 80 cases of patients with cerebral hemorrhage in basal ganglia with phlegm-heat internal block syndrome were selected and divided into the observation group and the control group according to the random number table method，with 40 cases in each group. The control group was given routine treatment for intracranial hypertension of cerebral hemorrhage，and the observation group was additionally treated with Angong Niuhuang Pills based on the treatment of the control group. The changes in intracranial pressure (ICP)，mean arterial pressure (MAP)， heart rate (HR)，traditional Chinese medicine (TCM) syndrome scores，total antioxidant capacity (T-Aoc)， superoxide dismutase (SOD) and BNP levels were compared before and after treatment between the two groups. Results： After treatment， the levels of ICP and MAP in the two groups were decreased when compared with those before treatment (P＜0.05)， and HR levels were increased when compared with those before treatment (P＜0.05)； the levels of ICP and MAP in the observation group were lower than those in the control group (P＜0.05)，and HR level was higher than that in the control group (P＜0.05). After treatment， the scores of TCM syndromes including severe headache， slow movement and somnolence were decreased when compared with those before treatment (P＜0.05)，and the above three scores in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of TAoc and SOD in the two groups were increased when compared with those before treatment (P＜0.05)， and BNP levels were decreased when compared with those before treatment (P＜0.05)；the levels of TAoc and SOD in the observation group were higher than those in the control group (P＜0.05)，and BNP level was lower than that in the control group (P＜0.05). Conclusion： The additional application of Angong Niuhuang Pills for patients with cerebral hemorrhage in basal ganglia with phlegm- heat internal block syndrome can effectively improve intracranial hypertension，relieve oxidative stress reactions and promote the recovery of heart function.