Abstract： Objective： To observe the clinical effect of Xiaoqinglong Decoction combined with Budesonide on bronchopneumonia with wind- cold attacking the lung syndrome. Methods ： A total of 92 patients with bronchopneumonia were selected and divided into the observation group and the control group according to the random number table method，with 46 cases in each group. The control group was treated with Budesonide，and the observation group was additionally treated with Xiaoqinglong Decoction based on the treatment of the control group. Both groups were treated for 4 weeks. The clinical effects were evaluated between the two groups. The changes in traditional Chinese medicine (TCM) syndrome scores，lung function indexes，inflammatory factor levels in serum，and immune function indexes were compared before and after treatment between the two groups. The adverse reactions during the treatment period were calculated between the two groups. Results： The total effective rate was 95.56% in the observation group，higher than that of 80.43% in the control group (P＜0.05). After treatment，the scores of various TCM syndromes in the two groups were decreased when compared with those before treatment (P＜0.05)； the scores of various TCM syndromes in the observation group were lower than those in the control group (P＜0.05). After treatment，the forced vital capacity (FVC)，forced expiratory volume in one second (FEV1)，peak expiratory flow (PEF)，and the ratio of FEV1 to FVC (FEV1/FVC) in the two groups were increased when compared with those before treatment (P＜0.05)；the FVC，FEV1，PEF，and FEV1/FVC in the observation group were higher than those in the control group (P＜0.05). After treatment，the levels of C-reactive protein (CRP) and tumor necrosis factor- α (TNF-α)，and interleukin-8 (IL-8) in the two groups were decreased when compared with those before treatment (P＜0.05)；the levels of CRP，TNF-α，WBC and IL- 8 in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of immunoglobulin G (IgG) and immunoglobulin M (IgM) in the two groups were increased when compared with those before treatment，and immunoglobulin E (IgE) levels were decreased when compared with those before treatment (P＜0.05)；the levels of IgG and IgM in the observation group were higher than those in the control group，and the IgE level was lower than that in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion：Xiaoqinglong Decoction and Budesonide for bronchopneumonia with wind- cold attacking the lung syndrome can promote symptom relief， improve lung and immune function of patients， and inhibit inflammatory factor expression in serum，which is safe and reliable.