Abstract： Objective： To observe the clinical effect of modified Wulingsan Decoction combined with Tacrolimus on nephrotic syndrome. Methods： A total of 120 cases of patients with nephrotic syndrome were divided into the control group and the treatment group according to the random number table method， with 60 cases in each group. Both groups were given basic treatment； the control group was additionally treated with Tacrolimus， and the treatment group was additionally treated with modified Wulingsan Decoction combined with Tacrolimus. Traditional Chinese medicine (TCM) syndrome scores，T lymphocyte subsets， kidney function indexes [blood urea nitrogen (BUN)， 24- hour urinary protein quantity， serum creatinine (SCr)] and the levels of bone morphogenetic protein- 7 (BMP- 7)， connective tissue growth factor (CTGF)，transforming growth factor-β1 (TGF-β1) in serum before and after treatment as well as the clinical effects were compared between the two groups. Results：After treatment，the total effective rate in the treatment group was higher than that in the control group (P＜0.05). After treatment， TCM syndrome scores，and the levels of CD8+，BUN，24-hour urinary protein quantity，SCr，CTGF，and TGF- β1 in serum in the two groups were decreased when compared with those before treatment (P＜ 0.05)， and the levels of BMP- 7 and CD4 + in serum， and CD4 +/CD8 + were increased (P＜0.05). After treatment， TCM syndrome score and the levels of CD8 +，BUN，24- hour urinary protein quantity，SCr， CTGF，and TGF-β1 in serum in the treatment group were lower than those in the control group，and the levels of BMP-7 and CD4+ in serum and CD4+/CD8+ were higher than those in the control group (P＜0.05). Conclusion： Modified Wulingsan Decoction combined with Tacrolimus has a significant curative effect in the treatment of nephrotic syndrome，which can improve the immune function and kidney function of patients.