Department of Pharmacy, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou Guangdong 510378,China 在期刊界中查找 在百度中查找 在本站中查找
Department of Pharmacy, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou Guangdong 510378,China 在期刊界中查找 在百度中查找 在本站中查找
Department of Pharmacy, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou Guangdong 510378,China 在期刊界中查找 在百度中查找 在本站中查找
Abstract: Objective: To screen the particle forming process of Jinbei Sanjie Granules. Methods: Under the premise of single factor investigation, orthogonal test was used, and paste to excipients, excipient A (soluble starch) to excipient B (powdered sugar), ethanol concentration and ethanol dosage (ethanol weight to excipient weight) were considered as factors. The four- factor and three- level L9(43) orthogonal test was carried out. The forming rate, angle of rest and bulk density were considered as indicators, and the optimal granulation process was initially screened by multi- index weighted scoring method. Results: The optimal granulation process was determined as paste to auxiliary material =1∶ 3, Soluble starch to powdered sugar = 1∶1,95% ethanol dosage was 5% of excipients. Conclusion:The optimized granulation process has high forming rate,uniform particles,good fluidity and good stability. The particle size and solubility meet the requirements,so the optimal process is reasonable and feasible.