Abstract：Objective：To observe the effect of auricular point seed- pressing combined with acupoint application on rehabilitation after orthopedic surgery. Methods：A total of 106 cases of patients underwent orthopedic surgery were selected and divided into the observation group and the control group according to the random number table method， with 53 cases in each group. After surgery， both groups were given routine nursing and treatment；the control group was additionally treated with acupoint application，and the observation group was additionally treated with auricular point seed-pressing based on the treatment of the control group. Both groups were treated for 1 week. The scores of Hamilton Depression Scale (HAMD)， Generic Quality of Life Inventory 74 (GQOL-74) and Visual Analogue Scale (VAS) were compared between the two groups； satisfaction and incidence of adverse events were recorded. Results： In 7 days after surgery，HAMD scores in the two groups were decreased when compared with those before surgery，and GQOL-74 scores were increased when compared with those before surgery，differences being significant (P＜0.05). HAMD score in the observation group was lower than that in the control group，and GQOL-74 score was higher than that in the control group， differences being significant (P＜0.05). In 12 hours and 24 hours after surgery，VAS scores in the observation group were lower than those in the control group in the same period， differences being significant (P＜0.05). The total satisfaction rate was 94.34% in the observation group，higher than that of 81.13% in the control group，the difference being significant (P＜ 0.05). The incidence of postoperative adverse events in the observation group was 3.77%，lower than that of 16.98% in the control group， the difference being significant (P＜0.05). Conclusion： Auricular point seed-pressing combined with acupoint application can effectively improve the poor mood and quality of life of patients after orthopedic surgery，relieve their postoperative pain，increase satisfaction，and reduce the incidence of adverse events.