Abstract：Objective：To observe the clinical effect of thumb-tack needling for subcutaneous needling combined with Azithromycin on mycoplasma pneumonia in children. Methods： A total of 60 cases of children with mycoplasma pneumonia were selected and divided into the study group and the control group according to the random number table method，with 30 cases in each group. The control group was treated with Azithromycin， and the study group was additionally treated with thumb- tack needling for subcutaneous needling based on the treatment of the control group. The levels of inflammatory factors [high-sensitivity C-reactive protein (CRP)，lactate dehydrogenase (LDH)，and serum ferritin (SF)] in serum before and after treatment， as well as the clinical effects， and the time for body temperature normalization， cough improvement and rales disappearance were compared between the two groups. Results： The total effective rate was 93.33% in the study group， and 73.33% in the control group， the difference being significant (P＜0.05). After treatment，the time for body temperature normalization，cough improvement， rales disappearance in the study group was shorter than that in the control group， the difference being significant (P＜0.05). Before treatment， there was no significant difference in levels of CRP， LDH， and SF in serum between the two groups (P＞0.05)； After treatment， the levels of CRP， LDH，and SF in serum in the two groups were decreased when compared with those before treatment (P＜ 0.05)， and all three indexes in the study group were lower than those in the control group (P＜0.05). Conclusion：Thumb-tack needling for subcutaneous needling combined with Azithromycin for mycoplasma pneumonia in children can improve the clinical effects， effectively suppress the body's inflammatory responses，and promote the recovery of the disease.