Abstract：Objective：To observe the clinical curative effect of the therapy of Chiqiao Qingre Decoction combined with western medicine on children with acute bronchitis of wind- heat invading the lung type. Methods：A total of 240 children with acute bronchitis of wind-heat invading the lung type were included and divided into the control group and the trial group according to random number table method， with 120 cases in each group. The two groups were treated with Pediatric Paracetamol Atificial Cow-bezoar and Chlorphenamine Maleate Granules and Ribavirin Granules，and the trial group was additionally treated with Chiqiao Qingre Decoction. Both groups were treated for 7 days. The levels of serum inflammatory factors， including hypersensitive C- reactive protein (hs- CRP)， interleukin- 6 (IL- 6)， tumor necrosis factor- α (TNF-α)，interleukin-1β (IL-1β) and interleukin-8 (IL-8)，were detected before and after treatment，and the improvement of bronchitis- related symptoms was recorded. The clinical effects and incidence of adverse reactions were compared between the two groups. Results：After treatment，the total effective rate in the trial group was higher than that in the control group (P＜0.05). The disappearance time of cough， the disappearance time of lung rales and the disappearance time of fever in the trial group were shorter than those in the control group，and the onset time of reducing fever was earlier than that in the control group， differences being significant (P＜0.05). Serum levels of IL-6，TNF-α，hs-CRP，IL-1β and IL-8 in the two groups were decreased when compared with those before treatment (P＜0.05). Serum levels of IL- 6， TNF-α，hs-CRP，IL-1β and IL-8 in the trial group were lower than those in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： The combination of Chiqiao Qingre Decoction and western medicine for children with acute bronchitis of wind- heat invading the lung type， can effectively inhibit inflammation， improve clinical effect，accelerate the relief of clinical symptoms，shorten the course of disease，and have great safety.