Abstract： Objective： To observe the effect of sitz bath with Compound Huangbai Liquid combined with red light irradiation on postoperative rehabilitation of perianal abscess with intense heat- toxin syndrome. Methods ： A total of 78 cases of patients with perianal abscess with intense heat- toxin syndrome were selected and divided into the observation group and the control group according to the random number table method，with 39 cases in each group. The control group was treated with red light irradiation， and the observation group was additionally treated with sitz bath with Compound Huangbai Liquid based on the treatment of the control group. Both groups were treated for 2 weeks. The clinical effects，traditional Chinese medicine(TCM) syndrome scores，wound healing situation，and the levels of inflammatory factors and growth factors were compared between the two groups. Results： The total effective rate of 2 weeks after operation was 100% in the observation group，higher than that of 89.74% in the control group (P＜0.05). The scores of anal swelling and pain，restless sleep at night，dry mouth and constipation，aversion to cold and fever，difficult urination，and fluctuation of the wound in the two groups were decreased when compared with those 1 day before operation (P＜0.05)， and the above six TCM syndrome scores in the observation group were lower than those in the control group (P＜0.05). The scores of Visual Analogue Scale (VAS) of wound， wound effusion， and wound edema in the two groups were decreased when compared with those 1 day after operation (P＜0.05)，and the above three scores in the observation group were lower than those in the control group (P＜0.05). The time for wound healing in the observation group was shorter than that in the control group (P＜0.05). The levels of interleukin- 6 (IL- 6)， interleukin- 8 (IL- 8)， and tumor necrosis factor- α (TNF- α) in serum in the two groups were decreased when compared with those 1 day before operation (P＜0.05)，and the levels of IL-6，IL-8，and TNF-α in serum in the observation group were lower than those in the control group (P＜0.05). The levels of transforming growth factor- β (TGF-β)，vascular endothelial growth factor (VEGF)，and epidermal growth factor (EGF) in serum in the two groups were increased when compared with those 1 day before operation (P＜0.05)，and the levels of TGF-β，VEGF，and EGF in serum in the observation group were higher than those in the control group (P＜0.05). Conclusion：For patients with perianal abscess with intense heat-toxin syndrome after operation，sitz bath with Compound Huangbai Liquid combined with red light irradiation can relieve the pain， exudation， and edema of the wound， inhibit the body's inflammatory responses， and promote the expression of growth factors and postoperative wound healing.