二草清肝合剂联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝病临床研究
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R575.5

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Clinical Study on Ercao Qinggan Mixture Combined with Polyene Phosphatidylcholine for Nonalcoholic Fatty Liver Disease
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    摘要:

    目的:观察二草清肝合剂联合多烯磷脂酰胆碱胶囊治疗非酒精性脂肪性肝病(NAFLD) 湿热蕴结 证的临床疗效。方法:选取104 例NAFLD 湿热蕴结证患者,按随机数字表法分成对照组和治疗组,每组 52 例。对照组给予多烯磷脂酰胆碱胶囊治疗,治疗组在对照组基础上给予二草清肝合剂治疗。2 组均治疗3 个月。 比较2 组临床疗效、生化指标、中医证候评分、氧化应激指标。结果:治疗后,治疗组总有效率94.23%,高 于对照组78.85%, 差异有统计学意义(P<0.05)。治疗后, 2 组血清谷草转氨酶(AST)、谷丙转氨 酶(ALT)、总胆固醇(TC)、甘油三酯(TG) 水平均较治疗前降低,治疗组血清AST、ALT、TC、TG 水平均 低于对照组,差异均有统计学意义(P<0.05)。2 组中医证候评分均较治疗前降低,治疗组中医证候评分低于 对照组,差异均有统计学意义(P<0.05)。2 组血清正五聚体蛋白3(PTX3)、超氧化物歧化酶(SOD)、谷胱 甘肽过氧化物酶(GSH-Px) 水平均较治疗前升高,治疗组血清PTX3、SOD、GSH-Px 水平均高于对照组,差 异均有统计学意义(P<0.05)。结论:二草清肝合剂联合多烯磷脂酰胆碱胶囊治疗NAFLD 湿热蕴结证临床疗 效较好,能改善肝功能、血脂状况,缓解临床症状,减轻氧化应激反应。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Ercao Qinggan Mixture combined with Polyene Phosphatidylcholine Capsules for nonalcoholic fatty liver disease (NAFLD) with damp- heat accumulation syndrome. Methods:A total of 104 cases of NAFLD patients with damp-heat accumulation syndrome were selected and divided into the control group and the treatment group according to the random number table method, with 52 cases in each group. The control group was treated with Polyene Phosphatidylcholine Capsules, and the treatment group was additionally treated with Ercao Qinggan Mixture based on the treatment of the control group. Both groups were treated for 3 months. The clinical effects, biochemical indexes, traditional Chinese medicine (TCM) syndrome scores and oxidative stress indexes were compared between the two groups. Results:After treatment,the total effective rate was 94.23% in the treatment group, higher than that of 78.85% in the control group, the difference being significant (P< 0.05). The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (TC),and triglyceride (TG) in serum in the two groups were decreased when compared with those before treatment,and the above four levels in the treatment group were lower than those in the control group, differences being significant (P<0.05). The TCM syndrome scores in the two groups were decreased when compared with those before treatment,and the TCM score in the treatment group was lower than that in the control group, differences being significant (P<0.05). The levels of pentraxin 3 (PTX3), superoxide dismutase (SOD) and glutathione peroxidase (GSH- Px) in serum in the two groups were increased when compared with those before treatment,and the above three levels in the treatment group were higher than those in the control group, differences being significant (P<0.05). Conclusion: Ercao Qinggan Mixture combined with Polyene Phosphatidylcholine Capsules for NAFLD with damp- heat accumulation syndrome can relieve clinical symptoms,improve liver function,and regulate blood lipid levels and oxidative stress reactions.

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苏林红,林军,柳侠平,叶小丹,陈剑.二草清肝合剂联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝病临床研究[J].新中医,2024,56(4):58-62

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  • 在线发布日期: 2024-02-28
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