Abstract： Objective： To observe the clinical effect of point application with Kanlisha on preventing breast cancer chemotherapy- induced nausea and vomiting (CINV). Methods： A total of 109 cases of patients with breast cancer undergoing chemotherapy were selected as the study objects， and were divided into the trial group and the control group according to the order of admission，with 54 and 55 cases in each group respectively. The control group was treated with routine antiemetic therapy and dietary guidance， and the trial group was additionally treated with point application with Kanlisha based on the treatment of the control group. The incidence and severity of nausea and vomiting from 24 hours to 7 days after chemotherapy in the two groups were observed， and the curative effect on acute vomiting and delayed nausea and vomiting was compared between the two groups. Results：In 24 hours to 7 days after chemotherapy，the incidence and severity of nausea in the trial group were lower than those in the control group，the difference being significant (P＜0.05). After treatment，the incidence of nausea in the trial group was decreased with the passage of time；there was a significant difference between the control group and the trial group when the incidence of nausea in the control group reached the peak on the third day after chemotherapy，and there was also a significant difference between the two groups on the fifth to seventh day after chemotherapy. The incidence of nausea in the trial group was lower than that in the treatment group at all time points after the overall treatment. From 24 hours to 7 days after chemotherapy， the incidence and severity of vomiting in the trial group were lower than those in the control group， the difference being significant (P＜0.05). After treatment，the incidence of vomiting in the control group was slightly decreased with the passage of time but still at a high peak value，while the incidence of vomiting in the trial group tended to a low trend； the change trend of the incidence of vomiting was significantly different between the two groups. After the overall treatment，the incidence of vomiting in the trial group was lower than that in the treatment group at each time point. The curative effective rate of acute vomiting and delayed vomiting was 100% in the trial group；the curative effective rate of acute vomiting was 87.3% in the control group，and the curative effective rate of delayed vomiting was 80.0% in the control group. The curative effect in the trial group was better than that in the control group，differences being significant (P＜0.001). Conclusion：Kanlisha point application can prevent the occurrence of CINV in breast cancer and effectively relieve acute and delayed nausea and vomiting above grade Ⅰ，and the operation is simple and feasible.