Abstract： Objective： To observe the prevention effect of wet- hot compress with Huzhang Sihuang Decoction on phlebitis caused by Sodium Aescinate. Methods：A total of 180 cases of patients underwent intravenous infusion of Sodium Aescinate were selected as the study objects and divided into the control group，the Magnesium Sulfate group and the Huzhang Sihuang Decoction group according to the order of admission， with 60 cases in each group. The control group was given routine nursing， with routine education and strengthened inspection before treatment， local skin conditions checking， and timely treatment；the Magnesium Sulfate group was given wet compressing with 50% Magnesium Sulfate；the Huzhang Sihuang Decoction group was given wet- hot compress with Huzhang Sihuang Decoction. The Magnesium Sulfate group and the Huzhang Sihuang Decoction group were given external application after 5 minutes of drug infusion and were removed after 30 minutes of infusion with Sodium Aescinate. The treatment was performed once a day for 4 days. The incidence of phlebitis and nursing satisfaction were compared among the three groups， and the changes of pain scores before and after treatment were compared among the three groups. Results： After 4 days of treatment， the incidence of phlebitis was 11.67% in the Huzhuang Sihuang Decoction group，23.33% in the Magnesium Sulfate group，and 33.33% in the control group. The incidence of phlebitis in the Huzhuang Sihuang Decoction group was lower than those in the Magnesium Sulfate group and the control group， the difference being significant (P＜0.05). After 4 days of treatment，the pain scores in the three groups were decreased when compared with those before treatment (P＜0.05)； single factor analysis of variance was used for comparison among the three groups， the difference being significant (P＜0.05)； the pain improvement in the Huzhuang Sihuang Decoction group was better than that in the Magnesium Sulfate group and the control group，the difference being significant (P＜0.05). Nursing satisfaction was 96.67% in the Huzhang Sihuang Decoction group， 90.00% in the Magnesium Sulfate group，and 80.00% in the control group，the difference being significant (P＜0.05). Conclusion： Wet- hot compress with Huzhang Sihuang Decoction can effectively prevent phlebitis caused by intravenous infusion of Sodium Aescinate， effectively reduce the pain of limbs at the puncture side，and improve the nursing satisfaction and medication compliance.