Abstract：Objective：To observe the clinical effect of acupuncture at Yingxiang point (LI 20) combined with modified Qingre Tongqiao Decoction for allergic rhinitis. Methods：A total of 98 cases of patients with allergic rhinitis were selected and divided into the reference group and the study group according to the random number table method，with 49 cases in each group. The reference group was treated with basic western medicine treatment，and the study group was additionally treated with acupuncture at Yingxiang point (LI 20) combined with modified Qingre Tongqiao Decoction based on the treatment of the reference group. Before and after treatment， the following indexes were compared between the two groups： transforming growth factor-β (TGF-β)，interleukin-4 (IL-4)，interleukin-5 (IL-5)，tumor necrosis factor- α (TNF- α)， soluble vascular cell adhesion molecule- 1 (sVCAM- 1)， interleukin- 33 (IL- 33)， atopic Immunoglobulin E (IgE)， colony stimulating factor (CSF)， eosinophils (EOS)， micro RNA- 487b (miR- 487b)， aquaporin 1 (AQP1)， nasal resistance (NR)， nasal mucociliary transport rate (MTR)， nasal mucociliary transport time (MTT)， nasal ciliary clearance velocity (MCV)， peak expiratory flow rate (PEF)， day-night variability rate (%) of PEF，the levels of forced expiratory volume in one second (FEV1)，and the scores of Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ). Clinical effects and adverse reactions were compared between the two groups. Results：The total effective rate was 95.92% in the study group， higher than that of 83.67% in the reference group (P＜0.05). After treatment，the levels of sVCAM-1 and IL-5 in the two groups were decreased (P＜0.05)，and the two levels in the study group were lower than those in the reference group (P＜0.05)；the levels of TGF- β and IL-10 in the two groups were increased (P＜0.05)，and the two levels in the study group were higher than those in the reference group (P＜0.05). After treatment， the levels of TNF- α， IL- 33， and AQP1 in the two groups were decreased (P＜0.05)， and the three levels in the study group were lower than those in the reference group (P＜0.05)；the level of miR- 487b in the two groups were increased (P＜0.05)，and the level in the study group was higher than that in the reference group (P＜0.05). After treatment，the levels of CSF，atopic IgE，and EOS in the two groups were decreased (P＜0.05)， and the three levels in the study group were lower than those in the reference group (P＜0.05). After treatment，the levels of MCV and MTR in the two groups were increased (P＜0.05)，and the two levels in the study group were higher than those in the reference group (P＜0.05)； the levels of NR and MTT in the two groups were decreased (P＜0.05)， and the two levels in the study group were lower than those in the reference group (P＜0.05). After treatment，day-night variability rates of PEF in the two groups were decreased (P＜0.05)，and the rate in the study group was lower than that in the reference group (P＜0.05)；the levels of FEV1 and PEF in the two groups were increased (P＜0.05)，and the two levels in the study group were higher than those in the reference group (P＜0.05). After treatment， the scores of symptoms and RQLQ in the two groups were decreased (P＜0.05)，and the above scores in the study group were lower than those in the reference group (P＜0.05). The total incidence of adverse reactions in the study group was lower than that in the reference group (P＜0.05). Conclusion： Acupuncture at Yingxiang point (LI 20) combined with modified Qingre Tongqiao Decoction for allergic rhinitis can improve the patient's immune response，suppress inflammation，enhance ventilation and nasal mucosal ciliary function，alleviate sensitization symptoms，improve clinical effects and quality of life，and reduce the incidence of adverse reactions.