Abstract： Objective： To observe the clinical effect of Gushen Jiedu Decoction combined with conventional western medicine therapy for hemodialysis patients with end- stage renal disease. Methods： A total of 110 cases of hemodialysis patients with end- stage renal disease were selected as the study objects and divided into the study group and the control group according to the random number table method，with 55 cases in each group. The control group was treated with conventional western medicine treatment， and the study group was additionally treated with Gushen Jiedu Decoction based on the treatment of the control group. Both groups were treated for 3 months. Clinical effects in the two groups were evaluated. Traditional Chinese medicine (TCM) syndrome scores，kidney function，microinflammatory reactions，and prognosis were compared between the two groups. Results：The total effective rate was 89.09% in the study group and 74.55% in the control group， the difference being significant (P＜0.05). After treatment， TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and each TCM syndrome score in the study group was lower than that in the control group (P＜0.05). After treatment，blood creatinine (SCr) and urea nitrogen (BUN) in the two groups were decreased when compared with those before treatment (P＜0.05)， and SCr and BUN in the study group were lower than those in the control group (P＜0.05). After treatment，the levels of interleukin-6 (IL- 6) and tumor necrosis factor-α (TNF-α) in serum in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of IL- 6 and TNF- α in serum in the study group were lower than those in the control group (P＜0.05). The one-year survival rate in the study group was 87.76%， and the mortality rate was 12.24%；the one-year survival rate and mortality rate in the control group were 70.73% and 29.27% respectively. There was significant difference in one-year survival and mortality rates between the two groups (P＜0.05). Conclusion： Gushen Jiedu Decoction combined with conventional western medicine therapy has good clinical effects in the treatment of hemodialysis patients with endstage renal disease， which can relieve clinical symptoms， improve kidney function， microinflammatory reactions，and prognosis，and extend their survival time.