Abstract：Objective：To observe the curative effect of the therapy of Yangwei Granules combined with western medicine on bile reflux gastritis (BRG) and its effects on serum inflammatory factors. Methods：A total of 80 BRG patients were selected and divided into the control group and the observation group according to the random number table method，with 40 cases in each group. The control group was given oral administration of Mosapride and Hydrotalcite，and the observation group was additionally treated with Yangwei Granules based on the treatment of the control group. The two groups were treated for 8 weeks. The clinical effects and incidence of adverse reactions in both groups were observed； the changes of traditional Chinese medicine (TCM) syndrome scores and levels of serum inflammatory factors， including epidermal growth factor (EGF)，interleukin-32 (IL-32)，transforming growth factor-β1 (TGF-β1) and nitric oxide (NO) were compared before and after treatment between the two groups. Results：The total clinical effective rate was 95.00% in observation group and 80.00% in control group with significant difference (P＜ 0.05). After treatment， the TCM syndrome scores of distention and fullness in the stomach cavity and abdomen， lack of appetite， fatigue and asthenia， nausea and vomiting， and sloppy stool in the two groups were decreased (P＜0.05)， and the above scores in the observation group were lower (P＜0.05). After treatment，the levels of EGF，IL-32 and TGF-β1 in the two groups were decreased (P＜0.05)，and the NO levels were increased (P＜0.05)；the levels of EGF，IL-32 and TGF-β1 in observation group were lower (P＜0.05)，and the NO level was higher than those in the control group (P＜0.05). The incidence of adverse reactions was 12.5% in the observation group and 10.00% in the control group without significance (P＞0.05). Conclusion： The therapy of Yangwei Granules combined with western medicine has a definite curative effect on BRG，which can mitigate the clinical symptoms and improve the inflammation levels with good safety.