Abstract： Objective： To observe the clinical effect of Chuanzhi Tongluo Capsules combined with western medicine for acute cerebral infarction with qi deficiency with blood stasis syndrome. Methods：A total of 90 cases of patients with acute cerebral infarction with qi deficiency with blood stasis syndrome were divided into the control group and the observation group， with 45 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Chuanzhi Tongluo Capsules based on the treatment of the control group. Both groups were treated for 14 days. The traditional Chinese medicine (TCM) syndrome scores， National Institutes of Health Stroke Scale (NIHSS) scores，Barthel Index (BI) scores，cerebrovascular reserve function (CVR) values and pulse indexes (PI) values were compared before and after treatment between the two groups. Thrombelastography parameters (angle of blood clot growth curve)，the time required for the blood clot to grow to 20 mm (K)， comprehensive coagulation index (CI)， maximum clot strength (MA) and serum indexes [interleukin- 6 (IL-6)，tumor necrosis factor-α (TNF-α)，S100 calc-binding protein β (S100β)，neuron-specific enolase (NSE)] were compared before and after treatment between the two groups； the clinical effects and the incidence of adverse reactions in the two groups were evaluated. Results： During the treatment period， three cases were fallen off in the control group and the observation group respectively， and the studies were completed on 42 cases in each group respectively. After treatment， the total effective rate was 80.95% in the control group and 95.24% in the observation group， the difference being significant (P＜ 0.05). After treatment，BI scores，CVR values and the levels of thrombelastography parameter K in the two groups were increased when compared with those before treatment (P＜0.05)， and TCM syndrome scores， NIHSS scores， PI values and levels of thrombelastography parameters including Angle， CI and MA were decreased (P＜0.05). After treatment，BI score，CVR value and the level of thrombelastography parameter K in the observation group were higher than those in the control group (P＜0.05)， and TCM syndrome scores， NIHSS score， PI value， and the levels of thrombelastography parameters including Angle， CI and MA were lower than those in the control group (P＜0.05). After treatment， the levels of IL-6，TNF-α，NSE，and S100β in serum in the two groups were lower than those before treatment (P＜ 0.05)，and the above levels in the observation group were lower than those in the control group (P＜0.05). During treatment， no adverse reaction occurred in the two groups. Conclusion： Chuanzhi Tongluo Capsules combined with western medicine has a definite curative effect in treating acute cerebral infarction with qi deficiency with blood stasis syndrome， which can improve cerebrovascular reserve function and coagulation function，reduce inflammatory responses and accelerate the recovery of neurological function， with high safety.