Abstract： Objective： To observe the clinical effect of the therapy of oral administration of Modified Shenqi Dihuang Decoction combined with point application with Euodiae Fructus on hypertensive nephrology (HN). Methods：A total of 104 HN patients were selected as the study subjects and divided into the control group and the study group according to the randomized grouping by computer program，with 52 cases in each group. The control group was treated with Irbesartan Tablets，and the study group was additionally treated with Modified Shenqi Dihuang Decoction combined with point application with Euodiae Fructus. The clinical effects， blood pressure， and levels of indexes of kidney function， including uromodulin (UMOD) and estimated glomerular filtration rate (eGFR)， and inflammatory factors， including transforming growth factor- β1 (TGF- β1) and interleukin- 6 (IL- 6)， were compared between the two groups. Results：The total effective rate was 94.23% in the study group，higher than that of 80.76% in the control group， the difference being significant (P＜0.05). After treatment， the diastolic and systolic pressure in both groups were decreased when compared with those before treatment (P＜0.05)，and the diastolic and systolic pressure in the study group were lower than those in the control group (P＜0.05). After treatment， the levels of UMOD and eGFR in both groups were increased when compared with those before treatment (P＜0.05)，and the above levels in the study group were higher than those in the control group (P＜0.05). After treatment， the levels of TGF- β1 and IL- 6 in both groups were decreased when compared with those before treatment (P＜0.05)，and the above levels in the study group were lower than those in the control group (P＜0.05). Conclusion： The therapy of oral administration of Modified Shenqi Dihuang Decoction combined with point application with Euodiae Fructus has a significant curative effect on HN，which can mitigate the clinical symptoms and inflammatory responses of the body，and improve the blood pressure and kidney function.