Abstract：Objective：To observe the clinical effect of Xuefu Zhuyu Decoction combined with Ibuprofen and Flunarizine for vascular headache of stasis obstructing the brain collateral type and its effect on cerebral hemodynamics. Methods： A total of 96 patients with vascular headache were selected as the research subjects and divided into the treatment group and the control group according to the random number table method， with 48 cases in each group. The control group was treated with Ibuprofen combined with Flunarizine， and the treatment group was additionally treated with Xuefu Zhuyu Decoction based on the treatment of the control group. The clinical effects and incidence of adverse reactions were compared between the two groups. The Visual Analogue Scale (VAS) scores of headache，the frequency and duration of attacks， and the levels of cerebral hemodynamic indicators such as systolic blood flow velocity (Vs)， mean blood flow velocity (Vm)， pulsatile index (PI)， and vascular resistance index (RI) were compared before and after treatment. Results： The total effective rate was 93.75% in the treatment group， and 75.00% in the control group，the difference being significant (P＜0.05). After treatment，the VAS scores of headache，and frequency and duration of attacks in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above three indexes in the treatment group were lower than those in the control group (P＜0.05). After treatment， the levels of Vs and Vm in the two groups were increased when compared with those before treatment (P＜0.05)， and the levels of PI and RI were decreased when compared with those before treatment (P＜0.05)；the levels of Vs and Vm in the treatment group were higher than those in the control group (P＜0.05)，and the levels of PI and RI were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 8.33% in the treatment group and 6.25% in the control group，there being no significant difference between the two groups (P＞0.05). Conclusion： The combination of Xuefu Zhuyu Decoction combined with Ibuprofen and Flunarizine has a significant curative effect in treating vascular headache of stasis obstructing the brain collateral type. It can effectively alleviate headache attacks，improve cerebral hemodynamics，and have no significant increase in adverse reactions.