Abstract:Objective:To observe the clinical effect of Huachansu Capsules combined with Docetaxel Injection and Carboplatin Injection on advanced ovarian cancer and its effect on cellular immune function. Methods:A total of 106 cases of patients with advanced ovarian cancer were divided into the control group and the treatment group according to the random number table method,with 53 cases in each group. The control group was treated with Docetaxel Injection and Carboplatin Injection,and the treatment group was additionally treated with Huachansu Capsules based on the treatment of the control group. The changes in cellular immune indexes [T lymphocyte subsets (CD4+,CD8+,CD4+/CD8+ ) and Functional Assessment of Cancer Therapy-Ovary Cancer (FACT-OV4) scores before and after treatment were compared between the two groups;clinical effects and incidence of adverse reactions were analyzed. Results:The total effective rate was 98.11% in the treatment group and 84.91% in the control group,the difference being significant (P<0.05). After treatment, the levels of CD4 + and CD4 +/CD8 + in the two groups were increased when compared with those before treatment (P<0.05),and CD8 + levels were decreased when compared with those before treatment (P<0.05);the levels of CD4 + and CD4 +/CD8 + in the treatment group were higher than those in the control group (P<0.05),CD8 + level was lower than that in the control group (P<0.05). After treatment,the physiological status,emotional status and additional attention scores of FACT- OV4 scale in the two groups were decreased when compared with those before treatment (P<0.05),and the scores of functional status and social status were increased when compared with those before treatment (P<0.05); the scores of physiological status, emotional status and additional attention in the treatment group were lower than those in the control group (P<0.05),and the scores of functional status and social status were higher than those in the control group (P<0.05). During the treatment period,the incidence of adverse reactions was 3.77% in the treatment group and 18.87% in the control group,the difference being significant (P<0.05). Conclusion:Huachansu Capsules combined with Docetaxel Injection and Carboplatin Injection has a better curative effect than simple chemotherapy with western medicine in the treatment of advanced ovarian cancer,and it can effectively improve the cellular immune function and quality of life of patients,with fewer adverse reactions.