Abstract： Objective： To observe the clinical effect of Hongjin Xiaojie Capsules combined with Leuprorelin Acetate for endometriosis. Methods：A total of 82 patients with endometriosis were randomly divided into the control group and the treatment group，with 41 cases in each group. The control group was treated with Leuprorelin Acetate Microspheres Sustained Release for Injection， and the treatment group was supplemented with Hongjin Xiaojie Capsules based on the treatment of the control group. The clinical effects and adverse reaction rates were compared between the two groups. The changes in traditional Chinese medicine (TCM) syndrome scores，levels of carbohydrate antigen 125 (CA125)，anti endometrial antibody (EMAb)， adiponectin (APN) and hepatocyte growth factor (HGF) in serum， the uterine volume， endometrial thickness and mass diameter were compared before and after treatment. Results： The total effective rate was 95.12% in the treatment group，and 78.05% in the control group，the difference being significant (P＜0.05). After treatment，the TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome score in the treatment group were lower than those in the control group (P＜0.05). After treatment，the endometrial thickness，uterine volume and mass diameter in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above three indexes in the treatment group were smaller than that in the control group (P＜0.05). After treatment， the levels of CA125， EMAb， and HGF in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of APN were increased when compared with those before treatment (P＜0.05)；the levels of CA125，EMAb and HGF in serum in the treatment group were lower than those in the control group (P＜0.05)，and the level of APN was higher than that in the control group (P＜0.05). The incidence of adverse reactions was 9.76% in the control group， and 4.88% in the treatment group，there being no significant difference between the two groups (P＞0.05). Conclusion：Hongjin Xiaojie Capsules combined with Leuprorelin Acetate Microspheres Sustained Release for Injection has a significant curative effect in treating endometriosis， which can improve the clinical symptoms and signs， regulate the levels of related serum cytokines in serum， and has no adverse reactions of the treatment.