Abstract： Objective： To observe the clinical effect of Huaier Granules on patients with advanced primary liver cancer undergoing transcatheter arterial chemoembolization (TACE). Methods ： A total of 120 cases of patients with advanced primary liver cancer were selected as the study objects and divided into the control group and the observation group according to the random number table method ， with 60 cases in each group. Both groups were treated with TACE；the control group was treated with routine western medicine， and the observation group was additionally treated with Huaier Granules based on the treatment of the control group. Both groups were treated for 30 days. The clinical effects， duration of adverse reactions， Karnofsky Performance Status (KPS) scores and serum alpha-fetoprotein (AFP) levels were compared before and after treatment between the two groups. Results： After treatment， the total clinical effective rate in the observation group was 88.33%，higher than that of 65.00% in the control group. The duration of adverse reactions such as fever， abdominal pain， nausea， vomiting， and hepatic dysfunction in the observation group was shorter than that in the control group (P＜0.05). In 2 and 4 weeks after surgery， KPS scores in the two groups were gradually increased (P＜0.05)， and the score in the observation group was higher than that in the control group at the same time point (P＜0.05)； traditional Chinese medicine syndrome scores in the two groups were gradually decreased (P＜0.05)，and the score in the observation group was lower than that in the control group at the same time point (P ＜ 0.05). In 2 and 4 weeks after surgery， the levels of serum AFP in the two groups were gradually decreased (P＜ 0.05)，and the level in the observation group was lower than that in the control group at the same time point (P＜0.05). Conclusion： Huaier Granules combined with western medicine for patients with advanced primary liver cancer undergoing TACE can significantly improve the clinical effect， shorten the duration of postoperative adverse reactions such as fever， abdominal pain， nausea， vomiting， and hepatic dysfunction，improve the quality of life of patients，and reduce the levels of serum AFP.