Abstract：Objective：To observe the clinical effect of modified Buzhong Yiqi Decoction combined with Linggui Bafa Acupuncture for cancer-related fatigue after radiotherapy for gastric cancer. Methods：A total of 84 cases of patients with cancer-related fatigue after radiotherapy for gastric cancer were selected and divided into the control group and the observation group according to the random number table method， with 42 cases in each group. The control group was treated with routine symptomatic and supportive treatment， and the observation group was treated with modified Buzhong Yiqi Decoction combined with Linggui Bafa Acupuncture. Both groups were treated for 8 weeks. Clinical effects， traditional Chinese medicine syndrome scores， the scores of Cancer-Related Fatigue Scale and quality of life， nutritional status， and the levels of inflammatory factors were compared between the two groups. The grading of nausea and vomiting was counted. Results：The total effective rate was 92.86% in the observation group， higher than that of 78.57% in the control group (P＜0.05). After treatment，the scores of poor appetite and lack of strength，withered-yellow complexion，dizziness and shortness of breath，and limb fatigue in the two groups were decreased when compared with those before treatment (P＜0.05)，and each score in the observation group was lower than that in the control group (P＜0.05). After treatment， the scores of Chinese version of the Brief Fatigue Inventory (BFI-C) and Clinical Fatigue Scale (CFS) in the two groups were decreased when compared with those before treatment， and the scores of Karnofsky Performance Scale and Activities of Daily Living (ADL) were increased (P＜0.05)； the scores of BFI-C and CFS in the observation group were lower than those in the control group， and the scores of Karnofsky Performance Scale and ADL in the observationg group were higher than those in the control group (P＜0.05). After treatment，the levels of prealbumin，albumin，transferrin in serum in the two groups were increased when compared with those before treatment，and the levels of interleukin-6 (IL-6)，interleukin-1β (IL-1β)，and tumor necrosis factor-α (TNF-α) in serum were decreased (P＜0.05)；the levels of prealbumin，albumin， transferrin in serum in the observation group were higher than those in the control group ， and the levels of IL-6， IL-1β，and TNF-α in the observation group were lower than those in the control group (P＜ 0.05). The total incidence of vomiting was 47.62% in the observation group，lower than that of 73.81% in the control group (P＜0.05). Conclusion： Modified Buzhong Yiqi Decoction combined with Linggui Bafa Acupuncture has a significant clinical effect in the treatment of cancer-related fatigue after radiotherapy for gastric cancer.