Abstract： Objective： To observe the curative effect of acupuncture combined with Olanzapine on schizophrenia and its effect on inflammatory factors and oxidative stress. Methods：A total of 84 cases of patients with schizophrenia were selected and divided into the control group and the observation group according to the random number table method，with 42 cases in each group. The control group was treated with Olanzapine， and the observation group was treated with acupuncture combined with Olanzapine. Clinical effects were compared between the two groups. The changes in the scores of Positive and Negative Syndrome Scale (PANSS) and Clinical Memory Scale (CMS)， as well as the levels of inflammatory factors [tumor necrosis factor-α (TNF-α)，interleukin-1β (IL-1β)，and interleukin-10 (IL-10)] and oxidative stress [malondialdehyde (MDA) and superoxide dismutase (SOD)] were compared between the two groups before and after treatment. Results：After treatment，the total effective rate was 95.24% in the observation group and 76.19% in the observation group， the difference being significant (P＜0.05). After treatment， the scores of PANSS and CMS in the two groups were decreased when compared with those before treatment (P＜0.05)， and the two scores in the observation group were lower than those in the control group (P＜ 0.05). After treatment，the levels of TNF-α and IL-1β in the two groups were decreased when compared with those before treatment (P＜0.05)， and the IL-10 levels were increased when compared with those before treatment (P＜0.05)；the levels of TNF-α and IL-1β in the observation group were lower than those in the control group (P＜0.05)， and the IL-10 level in the observation group was higher than that in the control group (P＜0.05). After treatment， the MDA levels in the two groups were decreased when compared with those before treatment (P＜0.05)，and the SOD levels were increased when compared with those before treatment (P＜0.05)；the MDA level in the observation group was lower than that in the control group (P＜0.05)，and the SOD level in the observation group was higher than that in the control group (P＜ 0.05). Conclusion：Acupuncture combined with Olanzapine for schizophrenia can enhance clinical effect and relieve symptoms，with a regulatory effect on inflammatory factors and oxidative stress levels.