Abstract： Objective： To observe the clinical effect of Liangxue Sanyu Decoction combined with pancreatic kallikrein for diabetic retinopathy. Methods：A total of 126 patients with diabetic retinopathy were selected and divided into the western medicine group， the Chinese medicine group and the combination group according to the random number table method，with 42 cases in each group. The western medicine group was treated with Pancreatic Kininogenase Enteric-Coated Tablets for oral use，the Chinese medicine group was treated with Liangxue Sanyu Decoction for oral use， and the combination group was treated with Liangxue Sanyu Decoction combined with pancreatic kallikrein. The three groups were treated continuously for 3 months. The traditional Chinese medicine (TCM) syndrome scores were evaluated in the three groups before and after treatment. The peak systolic flow velocity (PSV) and end diastolic blood flow velocity (EDV) of the ophthalmic artery ， as well as the levels of hypersensitive C-reactive protein (hs- CRP) ， interleukin-6 (IL-6)， and tumor necrosis factor - α (TNF - α) were detected before and after treatment. The visual function was detected before and after treatment in three groups. Results： After treatment， the TCM syndrome scores in the three groups were decreased when compared with those before treatment (P＜0.05)；the TCM syndrome scores in the combination group were lower than those in the western medicine group and the Chinese medicine group (P＜0.05). After treatment，the levels of PSV and EDV in the three groups were increased when compared with those before treatment (P＜0.05)； the levels of PSV and EDV in the combination group were higher than those in the western medicine group and the Chinese medicine group (P＜0.05). After treatment， the levels of hs-CRP，IL-6，and TNF-α in the three groups were lower than before treatment (P＜0.05)，and the levels of hs-CRP，IL-6，and TNF-α in the combination group were lower than those in the western medicine group and the Chinese medicine group (P＜0.05). After treatment，the best corrected visual acuity and retinal thickness in the three groups were increased when compared with those before treatment，and the grayscale values of visual field were decreased when compared with those before treatment (P＜0.05)； the best corrected visual acuity and retinal thickness in the combination group were higher than those in the western medicine group and the Chinese medicine group， and the grayscale value of visual field was lower than those in the western medicine group and the Chinese medicine group (P＜0.05). Conclusion： Liangxue Sanyu Decoction combined with pancreatic kallikrein for diabetic retinopathy can improve the clinical symptoms，reduce the levels of inflammatory factors in the body，and improve fundus hemodynamics and visual function.