Abstract：Objective：To observe the effect of Modified Taohong Siwu Decoction on lumbar function in osteoporotic vertebral compression fractures of blood stasis obstruction type. Methods：A total of 114 cases of patients with osteoporotic vertebral compression fractures of blood stasis obstruction type were divided into the control group and the observation group according to the random number table method ， with 57 cases in each group. The control group was treated with percutaneous kyphoplasty， and the observation group was additionally treated with Modified Taohong Siwu Decoction orally based on the treatment of the control group. Clinical effects were compared between the two groups. The changes in serum prostaglandin E2 (PGE2)， interleukin-17 (IL-17)， cyclooxygenase-2 (COX-2)， bone alkaline phosphatase (ALP)，osteoprotegerin (OPG)， the scores of 36-Item Short Form Health Survey (SF-36)， Visual Analogue Score (VAS) of pain，and Oswestry Disability Index (ODI) were compared between the two groups before and after treatment. Results：After treatment，the levels of PGE2，COX-2，and IL-17 in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above three levels in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of ALP and OPG in serum in the two groups were increased when compared with those before treatment (P＜0.05)， and the above two levels in the observation group were higher than those in the control group (P＜0.05). After treatment，the scores of VAS and ODI in the two groups were decreased when compared with those before treatment ， and SF-36 scores were increased when compared with those before treatment (P＜0.05)； the scores of VAS and ODI in the observation group were lower than those in the control group， and SF-36 in the observation group was higher than that in the control group (P＜0.05). The fracture healing time and the pain remission time in the observation group were shorter than those in the control group，the difference being significant (P＜0.05). The total effective rate was 96.49% in the observation group and 80.70% in the control group，the difference being significant (P＜0.05). Conclusion： For patients with lumbar function in osteoporotic vertebral compression fractures blood stasis obstruction type，Modified Taohong Siwu Decoction can help relieve inflammatory reactions， regulate bone metabolism indexes，promote the recovery of lumbar function，and enhance clinical effects.