Abstract： This paper introduces the clinical experience of Professor MAO Dexi in syndrome differentiation and treatment of obesity from deficiency and stagnation. Professor MAO believes that obesity is a symptom with deficiency at root and excess at branch；as the root of the obesity，deficiency manifested itself in the spleen-kidney depletion，and depression，as the branch，has manifestations of pathogenic heat，phlegm-damp，static blood，and other symptoms of pathogen excess，depression， and stagnation. There are five syndrome types of obesity，including the spleen deficiency and exuberant dampness，the stomach heat and damp-constraint，internal accumulation of damp-heat，qi stagnation and blood stasis，and binding of phlegm and stasis. As for treatment，Shenling Baizhu Powder，Qingwei Powder and Pingwei Powder， Huanglian Wendan Decoction， Chaihu Shugan Powder， and Daotan Decoction and Taohong Siwu Decoction can be used as the main prescriptions and modified based on syndrome differentiation；with treatment measures for both body and mind and the emphasis on spiritual regulation，good curative effects can be achieved.