Abstract： Objective： To observe the clinical effect of acupotomy combined with Tongmai Jiejing Decoction on ankle spasm after cerebral infarction. Methods：A total of 50 cases of patients with ankle spasm after cerebral infarction were divided into the control group and the treatment group according to the random number table method，with 25 cases in each group. The control group was treated with Tongmai Jiejing Decoction，and the treatment group was treated with acupotomy combined with Tongmai Jiejing Decoction. The changes in Clinic Spasticity Index (CSI) scores of ankle spasm，Functional Gait Assessment (FGA) scores，and 10-meter walking test (10 MWT) were compared before and after treatment between the two groups；the clinical effects and the incidence of adverse reactions were analyzed. Results：The total effective rate was 96.00% in the treatment group and 72.00% in the control group，the difference being significant (P＜0.05). After treatment，the scores of CSI indexes including tendon reflex，muscle tension and clonus in the two groups were decreased when compared with those before treatment (P＜ 0.05)，and the above three scores in the treatment group were lower than those in the control group (P＜ 0.05). After treatment，FGA scores in the two groups were increased when compared with those before treatment (P＜0.05)， and the FGA score in the treatment group was higher than that in the control group (P＜0.05). After treatment，step length，walking speed and step frequency in the two groups were increased when compared with those before treatment (P＜0.05)，and the energy consumption indexes were decreased when compared with those before treatment (P＜0.05)；the step length，walking speed and step frequency in the treatment group were higher than those in the control group (P＜0.05)，and the energy consumption index was lower than that in the control group (P＜0.05). During the treatment，the incidence of adverse reactions was 8.00% in the treatment group and 16.00% in the control group，there being no significant difference between the two groups (P＞0.05). Conclusion：Acupotomy combined with Tongmai Jiejing Decoction has a significant clinical effect in treating ankle spasm after cerebral infarction， which can alleviate spasm degree and improve gait and walking function， with relatively few adverse reactions.