Abstract： Objective： To investigate the signal transduction mechanism of electroacupuncture in spontaneously hypertensive left ventricular hypertrophy rats. Methods： Spontaneous hypertensive rats (SHR) were randomly divided into hypertensive left ventricular hypertrophy group，electroacupuncture point group，electroacupuncture non- point group，AT1- R siRNA group and STAT siRNA group. Wistar- Kyoto rats with normal blood pressure were used as control group，with 20 rats in each group. Blood pressure， cardiac structure changes，myocardial fibrosis，angiotensin Ⅱ(AngⅡ) concentration，angiotensin receptor 1 (AT1) mRNA，Janus kinase and expression of transcriptional signal transducers and activators (JAK/STAT) protein were observed before and after treatment. Results： The systolic blood pressure of rats in the electroacupuncture point group decreased after treatment，but the systolic blood pressure of rats in the left ventricular hypertrophy group，the non- point group of electroacupuncture，the AT1- R siRNA group and the STAT siRNA group did not decrease significantly after treatment，and the differences were statistically significant (P＜0.05). The left ventricular mass index (LVMI) in electroacupuncture point group was lower than that in hypertensive left ventricular hypertrophy group，electroacupuncture non-point group，AT1-R siRNA group and STAT siRNA group， and the difference was statistically significant (P＜0.05). The left ventricular short axis shortening rate (LVFS) in electroacupuncture point group was higher than that in hypertensive left ventricular hypertrophy group，electroacupuncture non-point group，AT1-R siRNA group and STAT siRNA group，and the difference was statistically significant (P＜0.05). HE staining showed that the heart volume and cross- sectional area of myocardium of rats in the electroacupuncture point group were smaller than those in the hypertensive left ventricular hypertrophy group. The levels of Ang Ⅱ in myocardial tissue，serum procollagen (PCⅢ)，laminin (LN) and hyaluronic acid (HA) in electroacupuncture point group were lower than those in hypertensive left ventricular hypertrophy group， with statistical significance (P＜0.05). The AT1mRNA level of myocardial tissue in electroacupuncture point group was lower than that in hypertensive left ventricular hypertrophy group， and the difference was statistically significant (P＜0.05). The expressions of JAK1 and STAT3 in hypertensive left ventricular hypertrophy group，electroacupuncture non-point group and AT1-R siRNA group were high，while the expressions of JAK1 and STAT3 in electroacupuncture point group were decreased，with statistical significance (P＜0.05). Conclusion： Electroacupuncture may reverse left ventricular hypertrophy by inhibiting the expressions of related cytokines and proteins in JAK/STAT pathway mediated by AT1.