Abstract： Objective： To observe the clinical effect of modified Liangxue Huaban Decoction on psoriasis vulgaris with internal retention of blood heat syndrome. Methods：A total of 88 cases of patients with psoriasis vulgaris were collected and divided into the control group and the treatment group according to the random number table method，with 44 cases in each group. The control group was treated with Avi A capsules； the treatment group was treated with modified Liangxue Huaban Decoction based on the treatment of the control group. The changes in Psoriasis Area and Severity Index (PASI)，Dermatology Life Quality Index (DLQI)， symptom scores of internal retention of blood heat， and hemorheology indexes before and after treatment as well as the clinical effects were compared the two groups. Results： After treatment， the total effective rate was 93.18% in the treatment group and 75.00% in the control group， the difference between the two groups being significant (P＜0.05). After treatment，the scores of PASI and DLQI in the two groups were decreased when compared with those before treatment (P＜0.05)，and the scores of PASI and DLQI in the treatment group were lower than those in the control group (P＜0.05). After treatment，the syndrome scores like skin rash color，skin rash burning sensation，itching，restlessness and irritability in the two groups were decreased when compared with those before treatment (P＜0.05)， and the syndrome scores of internal retention of blood heat syndrome in the treatment group were lower than those in the control group (P＜0.05). After treatment， the plasma viscosity and high and low shear blood viscosity in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above three indexes in the treatment group were lower than those in the control group (P＜0.05). Conclusion：Based on the routine treatment of western medicine，modified Liangxue Huaban Decoction can further reduce the symptoms and signs of patients with psoriasis vulgaris with internal retention of blood heat syndrome， improve the quality of life and hemorheology status， and enhance the curative effect.